祝鼎成

祝鼎成 博士 副教授

  联系方式: zhudc@hznu.edu.cn

【简介】

        工学博士，2021年入职杭州师范大学，加入材料与化学化工学院刘俊秋教授）领导的“仿生功能材料创新团队”，担任副教授职位。入职以来共主持了4项国家、省、市级项目，评为2023年度杭州市城西科创大走廊（海外）青年人才，入选了2024年浙江省青年科技人才引育工程库，是2023年“杭州市领军型创新创业团队引进培育计划”的核心成员，被认定为杭州市高层次c类人才。累计在材料科学、高分子科学、医/药学、应用化学等多学科交叉的国际综合性和专业性期刊上发表论文28篇，其中以第一（含共同）身份发表论文7篇，以通讯作者身份发表论文5篇，包括Science Advances, Advanced Materials, Advanced Functional Materials, Advanced Drug Delivery Reviews, Biomaterials等知名学术期刊。是MDPI出版社评审委员会成员、Frontiers in Materials期刊“手性纳米颗粒”专题的客座副编辑，受邀在两次国际会议上做口头报告。研究方向为研发远程无线遥控钙信号调控体系，调控细胞内离子浓度与细胞通讯，控制细胞和活体行为。

【研究方向】

   功能高分子；基因治疗；响应释放；钙信号通讯

【教育和工作经历】

   1.2021.01-至今：杭州师范大学，材料与化学化工学院，副教授

          2.2017.10-2020.12，德国汉堡大学，博士后，导师：Wolfgang Parak

          3.2010.09-2017.06，浙江大学，生物化工，博士，导师：申有青

          4.2006.09-2010.06，浙江大学，生物工程，学士

【荣誉与奖励】

   1.2015年获得德国德意志学术交流中心Tradition-Vertrauen–Zukunft项目奖学金

【主持科研项目】

   1.主持国家自然科学基金青年基金项目，构筑光响应智能囊泡用于调控细胞间钙信号长程传递（项目编号：22105055），30万元，2022.01–2025.12。

        2.主持浙江省基础公益研究计划，构筑光驱动智能微米马达用于调控细胞钙信号通讯（项目编号：LQ22E03001），10万元，2022.01–2025.12。

       3.主持高层次留学回国人员（团队）在杭创业创新项目，构筑光响应智能囊泡用于调控细胞间钙信号长程传递（项目编号：4095C50622039），主持，18万元，2023.01-2025.12

【代表性论著】

第一/通讯作者（包括共同一作）发表论文情况：12篇

       1. Zherui Zhang, Yuhao Luo, Yuanhong Ma, Yaofeng Zhou, Dingcheng Zhu*, Wanhua Shen*, Junqiu Liu*. Photocatalytic manipulation of Ca²⁺ signaling for regulating cellular and animal behaviors via MOF-enabled H₂O₂ generation. Sci. Adv. 2024, 10, eadl0263. (IF: 13.6)

      2. Cong Li, Yaqi Wu, Yihang Zhu, Jing Yan, Shengda Liu, Jiayun Xu, Shixin Fa, Tengfei Yan,* Dingcheng Zhu,* Yi Yan,* and Junqiu Liu*, Molecular motor-driven light-controlled logic-gated K⁺ channel for cancer cell apoptosis. Adv. Mater. 2024, 231252. (IF: 29.4)

        3. Yaqi Wu, Cong Li, Yanliang Wu, Jiayun Xu, Zhigang Ni, Ofer Reany, Tengfei Yan,* Dingcheng Zhu,* and Junqiu Liu*. A reversible light-driven biomimetic K⁺/Na⁺-exchanger controls cancer cell apoptosis. Adv. Funct. Mater. 2024, 2400432. (IF: 19.0)

      4. Dingcheng Zhu*, Huijie Yan, Yaofeng Zhou, Leroy M. Nack, Junqiu Liu, Wolfgang Parak, Design of disintegratable nanoassemblies to release multiple small-sized nanoparticles. Adv. Drug. Deliv. Rev. 2023, 197, 114854. (IF: 16.1)

      5.Dingcheng Zhu, Lili Feng, Neus Feliu, Andreas H. Guse, Wolfgang J. Parak*, Stimulation of local cytosolic calcium release by photothermal heating for studying intra- and inter-cellular calcium waves. Adv. Mater. 2021, 200826. (IF: 29.4)  

     6. Dingcheng Zhu, Huijie Yan, Zhuxian Zhou, Jianbin Tang, Xiangrui Liu, Raimo Hartmann, Wolfgang J. Parak, Youqing Shen^*, Neus Feliu^*, Influence of the modulation of the protein corona on gene expression using polyethylenimine (PEI) polyplexes as delivery vehicle. Adv. Healthcare Mater., 2021, 10, e2100125 (IF: 10.0).

      7. Nico Brkovic, Li Zhang, Jan N. Peters, Stephan Kleine-Doepke, Wolfgang J. Parak, Dingcheng Zhu*, Quantitative assessment of the release kinetics of various polymer-encapsulated molecular cargos by photothermal heating. SMALL, 2020, 16, 2003639 (IF: 13.3).

     8. Guowei Wang,# Dingcheng Zhu# (co-first authors), Zhuxian Zhou*, Ying Piao, Jianbin Tang, Youqing Shen*, A glutathione-specific and intracellularly labile polymeric nanocarrier for efficient and safe cancer gene delivery, ACS Appl. Mater. Interfaces, 2020, 12, 14825-14838 (IF: 10.383).

       9. Dingcheng Zhu, Sathi Roy, Ziyao Liu, Horst Weller, Wolfgang J Parak, Neus Feliu*, Remotely controlled opening of delivery vehicles and release of cargo by external triggers, Adv. Drug Deliv. Rev. 2019, 138, 117-132. (IF: 16.1)

      10. Huijie Yan#, Dingcheng Zhu# (co-first authors), Zhuxian Zhou*, Xin Liu, Ying Piao, Zhen Zhang, Xiangrui Liu, Jianbin Tang, Youqing Shen*, Facile synthesis of semi-library of low charge density cationic polyesters from poly(alkylene maleate)s for efficient local gene delivery. Biomaterials, 2018, 178, 559-569. (IF: 14.0).

     11. Dingcheng Zhu, Huijie Yan, Zhuxian Zhou, Jianbin Tang, Xiangrui Liu, Raimo Hartmann, Wolfgang J. Parak, Neus Feliu*, Youqing Shen*, Detailed investigation on how the protein corona modulates the physicochemical properties and gene delivery of polyethylenimine (PEI) polyplexes. Biomater. Sci. 2018, 6, 1800-1817. (IF: 6.6)

      12. Dingcheng Zhu, Huijie Yan, Xin Liu, Jiajia Xiang, Zhuxian Zhou*, Jianbin Tang, Xiangrui Liu, Youqing Shen*, Intracellular disintegratable polysulfoniums for efficient gene delivery. Adv. Funct. Mater. 2017, 27, 1606826. (IF: 19.0)