勤慎论道 第九十讲 汪君博士谈“Facile Access to Chiral Phosphorus Compounds via Transition Metal-catalyzed Asymmetric Hydrophosphination”

报告题目:Facile Access to Chiral Phosphorus Compounds via Transition Metal-catalyzed Asymmetric Hydrophosphination

报告人: Jun (Joelle) Wang (汪君)

单 位：Hong Kong Baptist University (HKBU)

时 间：2023年4月12日上午10:30-11:30

地 点：仓前校区 勤园17-208

邀请人：杨丽敏 副教授

报告人简介:

    汪君博士于兰州大学取得本科学位，中国科学院上海有机化学研究所取得硕士学位，香港理工大学获得博士学位，随后加入美国德州大学西南医学中心从事博士后研究。2012-2020年期间，任职南方科技大学化学系助理教授、副教授。2020年，加入了香港浸会大学化学系任职副教授。汪博士的主要研究领域为不对称催化、有机合成方法学和药物化学。近年来，围绕含膦的手性化学物的设计与合成；黄酮类化合物的不对称合成及其生物活性应用；杂环类化合物的氢官能团化反应；植物中天然产物的后期官能化改造以及药妆品中小分子的结构修饰，在国内外核心学术期刊发表了包括CCS Chem; J. Am. Chem. Soc.; Angew. Chem. Int. Ed.; Nat. Catal.; Nat. Commun.; Sci. Adv.; Chem. Sci.; ACS Catal.等研究论文及综述60余篇，获得多项发明专利。2017，获得Thieme Chemistry Journals Award；2022年入选香港青年科学院(YASHK)院士。

报告内容简介：

         Asymmetric catalysis is a very broad and exciting field. In spite of hundreds of chiral ligands developed, phosphine ligands are keeping their prestigious role as the most powerful and frequently-used ligands. With the exceptionally high demand of chiral phosphine ligand, it is significant to develop efficient methods for construction these chiral organophosphorus compounds. Transition metal-catalyzed asymmetric hydrophosphination is the most direct pathway for the synthesis of chiral phosphine compounds. Recently, our group developed asymmetric hydrophosphination of alkenes, alkynes, allenes and cyclopropenes.^1-5 These approaches allowed concise, direct, modular and unprecedented accesses to potentially valuable chiral phosphorus compounds.

参考文献：

1.   Lu, Z.; Zhang, H.; Yang, Z.; Ding, N.; Meng, L.; Wang, J.* ACS Catal. 2019, 9, 1457-  1463.

2.  Yang, Z.; Gu, X.; Han, L.-B., Wang, J.* Chem. Sci. 2020, 11, 7451-7455

3.   Yang, Z.; Wang, J.* Angew. Chem. Int. Ed. 2021, 60, 27288 –27292

4.   Zhang, Y.; Jiang, Y.; Li, M.; Huang, Z.; Wang, J.* Chem. Catal. 2022, 2, 3163–3173 (Front Cover).

5.   Yang, Z.-P.; Du, Q.-W.; Jiang, Y.-X.; Wang, J.* CCS Chem. 2022, 4, 1901–1911.

6.  Cai, B.; Cui, Y.; Zhou, J.; Wang, Y.-B.; Yang, L.*; Tan, B.*; Wang, J.* Angew. Chem. Int. Ed. 2023, 62, DOI: 10.1002/anie.202215820.

7.   Yang, Q.; Zhou, J. Wang, J.* Chem. Sci. 2023, 14, DOI: 10.1039/D2SC06950D